The importance of considering augmented renal clearance in critically ill patients Motoki FUJII 1 , Hideto YASUDA 1 1Department of Intensive Care Medicine Kameda Medical Center pp.165-174
Published Date 2020/1/1
DOI https://doi.org/10.11477/mf.3102200722
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Glomerular filtration increasing beyond the normal range in critically ill patients is a recently recognized phenomenon termed Augmented Renal Clearance (ARC) which has attracted attention. ARC is defined as creatinine clearance >130ml/min/1.73m2. Younger age, male gender, and status post traumatic injury are risk factors. Since ARC enhances the clearance of renally eliminated antibiotics, there are concerns about poor outcomes and emergence of bacterial resistance due to low serum antibiotic concentrations. However, the pathophysiology of ARC and optimal drug dosing strategies remain largely unknown due to the short history of the concept of ARC.

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