顆粒球輸血

Granulocyte Transfusion

　濃縮顆粒球輸血は，敗血症性好中球減少に対する血液成分療法として確立した方法に急速になりつつある．細胞の適当な量を集めて輸血することと，試験管内と生体内での効果を評価するについての問題点と不確実な点が述べられている．濃縮顆粒球の適当な貯蔵条件と，顆粒球輸血に際しての，ヒト白血球抗原と好中球特異抗原については，更に研究が必要である．より強力な化学療法剤の使用の増加は，顆粒球の援助の必要性が広がり続けるであろう．

Granulocyte concentrate transfusion^*1 is quickly becoming an established form of blood component therapy for the septic neutropenic patient. The problems and uncertainties in collecting and transfusing adequate quantities of cells and in evaluating efficacy in vitro and in vivo^*2 are described. More studies are needed on proper storage conditions for granulocyte concentrates and on the relative importance of HLA and neutrophil-specific antigens in granulocyte transfusion. With increasing use of more potent chemotherapeutic regimens^*3, the need for granulocyte support will continue to expand.