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Valuable biomarkers for the diagnosis of iron overload Takahiro Suzuki 1 1Division of Hematology, Department of Medicine, Jichi Medical University Keyword: 鉄過剰症 , 活性酸素種 , フェリチン , トランスフェリン , トランスフェリン非結合鉄 pp.1044-1051
Published Date 2012/10/15
DOI https://doi.org/10.11477/mf.1542103154
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Iron overload is diagnosed by quantification of iron in the liver. However, performing biopsy is not adequate for many patients due to their cytopenias. Therefore, in clinical practice, alternative biomarkers are utilized for evaluating iron overload. Serum ferritin and saturation of transferrin are essential markers for the diagnosis, and quantification of tissue iron by MRI is also useful. Reliable methods for measuring NTBI (non transferrin-bound iron), the essential substance highly reactive to microorgans, have been developed. For the appropriate diagnosis and treatment of iron overload, we need detailed knowledge about these iron-related biomarkers.


Copyright © 2012, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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