Rinsho Kensa Volume 56, Issue 4 (April 2012)

Clinical significance and evaluation of various markers necessary for diagnosis of infections Miyuki Hasegawa 1 , Intetsu Kobayashi 1 1Department of Infection Control and Prevention, School of Nursing, Faculty of Medicine, Toho University Keyword: 炎症性疾患マーカー , 抗原検出 , CRP , PCT , エンドトキシン , サイトカイン , 1 , 3-β-D-グルカン pp.387-391
Published Date 2012/4/15
DOI https://doi.org/10.11477/mf.1542102980
  • Abstract
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The standard method for the diagnosis of infections is cultivation or direct detection of pathogen antigens. However, the cultivation test is time-consuming. In addition there are some pathogens whose growth is difficult or impossible to detect and there is a limit to detecting antigens of many pathogens. At present the detection of the pathogen antibodies or genes and microscopic examination of test specimens are used for the diagnosis of infections. The present paper describes test methods other than the above-mentioned methods that assist in the diagnosis of infections. CRP, PCT and cytokines are proteins that respond to the pathogens and are produced in vivo in the patients. These proteins are available as markers for inflammatory disease but not available as a single test item in making the diagnosis of infections. On the other hand, the causative microorganisms can be presumed to some extent by near-cutoff values of endotoxin or 1,3-β-D-glucan which were structural components of pathogens. It is essential for the exact diagnosis of infections to grasp the pathological condition of patients and to detect the pathogens at the same time in any of the subjects.

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56巻4号 (2012年4月)
電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院