Sjögren's syndrome Takayuki Sumida 1 1Department of Internal Medicine, University of Tsukuba Keyword: アナログペプチド , 抗M3R抗体 , M3R反応性T細胞 , Sjögren症候群 , T細胞抗原受容体 pp.1179-1185
Published Date 2011/10/30
DOI https://doi.org/10.11477/mf.1542102800
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Sjogren's syndrome (SS) is chronic inflammatory disease in the salivary glands, lacrymal glands, and other tissues, resulting in dry mouth and dry eyes. Histological examination has shown the remarkable infiltration of mononuclear cells, especially CD4+ T cells, destruction of the epithelial duct, and fibrosis in their respective regions. The pathogenesis might be due to autoimmune disease, b ecause the disease gives rise to several autoantibodies such as anti-SS-A Ab, anti-SS-B Ab, and anti-M3R Ab. Recently, it has been reported that M3R reactive T cells are also involved in autoimmune reaction in sialoadenitis. The clarification of the molecular mechanism in SS should shed light on the development of a new therapeutic strategy.

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