Rinsho Kensa Volume 55, Issue 11 (October 2011)

The role of regulatory T cells in health and disease Junko Nishio 1 1Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo Keyword: 制御性T細胞 , 自己免疫疾患 , Foxp3 pp.1099-1112
Published Date 2011/10/30
DOI https://doi.org/10.11477/mf.1542102790
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Foxp3-expressing regulatory T cells (Treg cells) contribute significantly to the maintenance of peripheral tolerance. In addition to restraining autoimmunity, Treg cells play roles in the regulation of inflammation, infection and tumor growth. Foxp3 expression is indispensable for differentiation and suprressor function of Treg cells. Although most peripheral Treg cells are thymus-derived natural Treg cells (nTreg cells), induced Treg (iTreg cells) cells differentiated from peripheral naïve CD4T cells comprise probably a small portion of the peripheral Treg cells. More attention is paid to impaired Treg cell-mediated regulation as a possible mechanism in human autoimmune diseases.

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55巻11号 (2011年10月)
電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院