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In vivo imaging reveals chronic inflammation and abnormal immunity in obese adipose tissue Satoshi Nishimura 1,2,3 , Mika Nagasaki 1,4 1Department of Cardiovascular Medicine, The University of Tokyo 2Translational Systems Biology and Medicine Initiative, The University of Tokyo 3PRESTO, Japan Science and Technology Agency 4Computational Diagnostic Radiology and Preventive Medicine, The University of Tokyo Keyword: 慢性炎症 , CD8陽性 T細胞 , 脂肪組織 , マクロファージ pp.574-580
Published Date 2011/6/15
DOI https://doi.org/10.11477/mf.1542102645
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Metabolic syndrome is a major risk factor of cardiovascular events, and obese visceral adipose tissue remodeling and malfunctioning based on chronic inflammation and local immunological changes plays a central role. To assess dynamic interplay between multiple cell-types in obese adipose, a visualization technique in vivo was therefore developed. In vivo imaging revealed close spatial and temporal interrelationships between angiogenesis and adipogenesis in obese adipose. Increased leukocyte-platelet-endothelial cell interactions in the microcirculation of obese adipose were also observed, a hallmark of inflammation. We also found that large numbers of CD8 effector T cells infiltrated into obese adipose. CD8 T cells contribute to the macrophage recruitment in obese adipose tissue, and adipose tissues inflammation in obesity.


Copyright © 2011, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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