Rinsho Kensa Volume 55, Issue 5 (May 2011)

Colorectal cancer stem cell Hiroshi Katoh 1 , Keishi Yamashita 1 , Masahiko Watanabe 1 1Department of Surgery, Kitasato University School of Medicine Keyword: 大腸癌 , 癌幹細胞 , 腺窩 , CD133 , Lgr5 pp.489-494
Published Date 2011/5/15
DOI https://doi.org/10.11477/mf.1542102622
  • Abstract
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  • Reference

Colorectal cancer (CRC) eventually occurs through the accumulation of genetic mutations and/or epigenetic modifications. Recently, the presence of organ-specific stem cell has been suggested, and the genetic alterations are thought to accumulate in the stem cells, leading to malignant transformation. In this cancer stem cell (CSC) theory, less than a few % of cancer cells have the ability to regenerate a tumor. In this review, we will first consider the knowledge of colonic crypt and normal colonic stem cells. Then, we will summarize the recent studies of CRC CSC and discuss their clinical relevance.

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55巻5号 (2011年5月)
電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院