雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Dengue fever Tomohiko Takasaki 1 1Department of Virology 1, National Institute of Infectious Diseses Keyword: デングウイルス , デング熱 , デング出血熱 pp.1435-1439
Published Date 2010/10/30
DOI https://doi.org/10.11477/mf.1542102458
  • Abstract
  • Look Inside
  • Reference

No dengue epidemic has yet been reported in Japan after World War II, but imported cases numbered about 100 cases per year because of the increase in Japanese tourists traveling to endemic tropical and subtropical areas. Dense urban overpopulation due economic growth also provides breeding sites the mosquito-human-mosquito transmission cycle because the vector lives in urban area. Live attenuated dengue vaccines have been developed for their inexpensiveness because of economic conditions in the epidemic developing countries. There are four dengue virus types, and vaccine developed against one type works only poorly against another type, with inadequate vaccine use increasing the risk of hemorrhage and shock syndrome when the infection reemerges. A vaccine must induce antibodies effective against all four types, which has greatly retarded vaccine development. Pediatric vaccination must provide at least antibodies effective against all 4 types to get consent from guardians. There are problems in where the clinical trials can be conducted. Laboratory diagnosis and surveillance systems should be established there. Another problem is whether the vaccine targets dengue fever or dengue hemorrhagic fever.


Copyright © 2010, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

関連文献

もっと見る

文献を共有