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Lipoproteins and atherosclerosis Takashi Miida 1 , Satoshi Hirayama 1 1Department of Clinical Laboratory Medicine, Juntendo University School of Medicine Keyword: プラーク , マクロファージ , コレステロール pp.345-351
Published Date 2010/4/15
DOI https://doi.org/10.11477/mf.1542102267
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Lipoproteins are particles which carry lipids in the blood circulation. In the animals whose serum cholesterol levels are very low, atherosclerosis is hardly detected. In humans, however, risk factors including dyslipidemia promote atherosclrosis. Clinical symptoms emerge usually after middle age. Histologically, cholesterol derived from macrophages accumulates in the atheromatous plaque. Such cholesterol is degradation products of serum lipoprpteins (LDL, IDL, and remnants). On the other hand, HDL is anti-atherogenic lipoprotein which inhibits development of atheroscerosis, and promotes its regression. Protein moiety of lipoproteins (broadly-defined "apolipoproteins") is an important determinant for the effects of lipoproteins on atherosclerosis.


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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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