反復性中耳炎に対する抗微生物薬と和漢薬との協同効果

SYNERGISITIC EFFECT OF ANTIBIOTICS AND CHINESE DRUG ON RECURRENT OTITIS MEDIA

　I．緒言

　化膿性中耳炎（中耳炎）の主な原因菌とされているものはStreptococcus pyogenes（group A），Staphylococus aureus，Haemoohilus influenzaeなどであり，いずれも病原性の明らかな細胞外寄生菌（extracellular paracites）である。これらの細菌については高い抗菌活性を有する抗微生物薬も数多く存在し，感受性を考慮した投薬を行えば短期間に耳漏の停止をみる場合が多い。

　しかし最近は，いったん症状の消退をみながら短時日のうちに症状の再燃により再び受診を求める症例にしばしば遭遇する。このような症例はいわゆる反復感染症と考えられ，免疫不全症候が多くの場合認められる^1）。

　So-called "recurrent infection" has recently been increased in many clinical fields, and this may intimately be associated with the function of the immune system.

　Clinical efficacy of antibiotics with or without combination with chinese drug was evaluated and the related host defense mechanism was studied in 14 patients who had recurrent acute or chronic otitis media, seen in our hospital between May 5 and August 9, 1979.

　The result showed that the combination of antibiotics and chinese drug was more effective than antibiotics alone to prevent the recurrence. It seems from the results of this studies that chinese drug activate the immune system.