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CHRONIC GRANULOMATOUS DISEASE, A CASE REPORT Keiichi Ichimura 1,2 pp.349-358
Published Date 1979/5/20
DOI https://doi.org/10.11477/mf.1492208899
  • Abstract
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 Chronic granulomatous disease is regarded as a syndrome of recurrent suppurative infection of the skin and reticuloendothelial organs associated with an inability of patients' phagocytes to kill bacteria which do not produce hydrogen peroxidase. The age of onset is usuall by one year.

 A case of fifteen month-old boy with this disease was presented.

 The first symptom of perianal abscess appeared by eight months of his life followed by lymphadenopathy and eczematous dermatitis near the external nares and external ears. The left forehead was struck by a falling book from the mother's hand and osteomyelitis with a fistula was developed.

 Surgery revealed a massive granuloma invading the lower part of the left frontal bone with a bony defect measured two centimeters in diameter and a centimeter in depth. Curretage of granulation tissue and circumscribed bone marrow and removal of the fistula yielded a good result.

 By negative NBT test which suggested failure of the patient's phagocytes to reduce nitroblue tetrazolium the diagnosis of chronic granulomatous disease was made.

 Though there were few reports of this disease in otolaryngology, each sign or symptom is popular in our field. Therefore the knowledge of and the interest to this disease should be broad-end in the pediatric otolaryngology.


Copyright © 1979, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 印刷版ISSN 0386-9679 医学書院

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