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English
研究
くも膜下出血後の血液凝固線溶系の検討
The Relationship between the Severity of a Neurological Condition and the Blood Coagulation/fibrinolytic System in Patients with Spontaneous Subarachnoid Hemorrhage
草彅 博昭
1,4
,
寺本 明
2
,
志村 俊郎
3
Hiroaki KUSANAGI
1,4
,
Akira TERAMOTO
2
,
Toshiro SHIMURA
3
1博慈会記念総合病院脳神経外科
2日本医科大学脳神経外科
3日本医科大学附属多摩永山病院脳神経外科
4日本医科大学付属第二病院脳神経外科
1Department of Neurosurgery, Hakujikai Memorial Hospital
2Department of Neurosurgery, Nippon Medical School
3Department of Neurosurgery, Tama-nagayama Hospital, Nippon Medical School
4Department of Neurosurgery, Nippon Medical School Dai-ni Hospital
キーワード:
subarachoid hemorrhage
,
fibrinolysis
,
hemostasis
,
coagulation
Keyword:
subarachoid hemorrhage
,
fibrinolysis
,
hemostasis
,
coagulation
pp.399-403
発行日 2002年4月10日
Published Date 2002/4/10
DOI https://doi.org/10.11477/mf.1436902197
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Ⅰ.はじめに
くも膜下出血後,特にその重症例において血液凝固線溶系が亢進することはよく知られている3-5,7-9,12,14,18-20).しかしこれまでは,凝固線溶系のうち代表的な項目のみを調べた報告がほとんどであった.そこで今回われわれは脳動脈瘤破裂によるくも膜下出血の患者を重症例と軽症例に分け,凝固線溶系について詳細に測定を行い,その傾向について検討を行ったので報告する.
In order to examine the relationship between the hemostatic systems and the severity of neurological changes, shortly after spontaneous subarachnoid hemorrhage (SAH) we reviewed 30 patients who had been admitted within 6 hours after the onset of SAH. Peripheral blood samples were obtained within 6 hours of the onset of SAH. There was a significant correlation between increased values of serum antithrombin Ⅲ, thrombin-antithrombin Ⅲ com-plexes, fibrinopeptide Bβ15-42, D-dimers, and the neurological severity of SAH.
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