Masayuki SHINTAKU 1 , Shouji NAKATSU 2 , Shin-ichirou OKAMOTO 2 1Department of Pathology, Osaka Red Cross Hospital 2Department of Neurosurgery, Osaka Red Cross Hospital Keyword: glioblastoma , “adenoid” formation , immunohistochemistry , ultrastructure pp.359-365
Published Date 2000/4/10
DOI https://doi.org/10.11477/mf.1436901875

A surgical case of glioblastoma which showed a pronounced “adenoid” (or “epithelioid”) appearance was reported. The patient was an 81-year-old woman, who presented with unsteady gait. Neuroradiological ex-amination revealed three discrete mass lesions located in the 1-frontal, 1-parieto-occipital, and r-occipito-temporal lobes. Despite the subtotal removal of two of the three lesions and postoperative chemotherapy and radiotherapy, the patient died 21 months after the onset of illness. Histopathological examination of the resected tumors revealed typical features of glioblastoma in the peripheral region of the tumor. In the central region, the tumor cells were arranged in a papillary fashion or formed solid, sheet-like cell nests and were surrounded by fibrous connective tissue septa. Although the histopathological appearance of the tumor closely resembled metastasis of adenocarcinoma, the immunohistochemical and ultrastructural stu-dies of the tumor failed to detect evidence of a definite differentiation towards epithelial cells.


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