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201TlCl Accumulation Dynamics in Glioma with Different Grades of Malignancy : an investigation using dynamic SPECT Nobuo SUGO 1 , Hitoshi OHISHI 1 , Takao KUROKI 1 , Takashi OHTSUKA 1 , Toshiyuki KANO 1 , Toshiaki MITO 1 , Yoshikatsu SEIKI 1 , Iekado SHIBATA 1 1Department of Neurosurgery, Toho University School of Medicine Keyword: glioblastoma multiforme , anaplastic astrocytoma , dynamic SPECT , thallium chloride pp.881-887
Published Date 1998/10/10
DOI https://doi.org/10.11477/mf.1436901622
  • Abstract
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Dynamic SPECT was performed using in a total of 201TlCl in a total of 21 gliomas, 14 cases of glioblastoma multi-forme (GM) and 7 cases of anaplastic astrocytoma (AA), to investigate the relationship between test re-sults and malignancy. The accumulation of isotope (counts/pixel) in the tumor was measured every 3 mi-nutes with dynamic SPECT. The initial 3-minute value was reduced from subsequent accumulations(counts/minute) to obtain the time-activity curve (TAC. Thallium index (TL, index), the ratio of 15-mi-nute accumulation in the tumor to that in the same region of the contralateral normal brain, was also calcu-lated. Tl- index was significantly higher (p<0.05, Mann-Whitney test) in GM (6.25±1.97) thanin AA(4.10 ± 1.66), although no clear differential value could be determined between the two. TAC in the GMgroup showed that compared with the initial 3-minute value, accumulation increased significantly(p<0.05)at every measurement point after isotope injection : 6 minutes, 0.660±0.671 ; 9 minutes, 1.322±1.319 ; 12minutes, 1.315±1.632 and 15 minutes, 1.234±1.552. The increase in isotope accumulation in thetumor after6 minutes or later was noted in 11 of the 14 cases in the GM group. In the AA group, however, therewereno significant differences between the initial 3-minute value and value after 6 minutes (0.283±0.462), 9mintes -0.574±0.681), 12 minutes (-0.690±0.611) and 15 minutes (-0.707±0.636) afterisotope injec-tion. A decrease in isotope accumulation in the tumor after 6 minutes or later was noted in 6 of the7 casesin the AA group. Compared with static SPECT, dynamic SPECT, which can be performed easily andquickly, is more useful in clinical settings because of its high ability to differentiate the grade ofmalignan-cy of gliomas.


Copyright © 1998, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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