雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Changes in metabolism and peritumoral circulation after radiosurgery of metastatic brain tumors:evaluation by three dimensional dual isotope SPECT Nobuo SUGO 1 , Iekado SHIBATA 1 , Masaaki NEMOTO 1 , Akio NEMOTO 1 , Hitoshi OHISHI 1 , Takao KUROKI 1 , Yoshikatsu SEIKI 1 , Hideo TERAO 1 , Hideki TAKAHASHI 2 , Masaaki TAKANO 2 , Jyunichi SUGITA 3 1Department of Neurosurgery 2Department of Neurosurgery, RI Department of Radiology 3Toho University School of Medicine K. G. T. Keyword: metastatic brain tumor , SPECT , 3 dimensional image , radiosurgery pp.515-521
Published Date 1997/6/10
DOI https://doi.org/10.11477/mf.1436901401
  • Abstract
  • Look Inside

Concurrent use of two different isotopes, 201T1C1 and 123Ⅰ-IMP, in SPECT is useful in separative evalua-tion of tumor metabolism and peritumoral circulation. Three dimensional SPECT employed in our study has an obvious advantage over two dimensional SPECT for its accurate imaging of tumors and peritumoural areas. Changes of tumor metabolism and regional circulation in peritumoral edematous tissues were investigated by fused 3-D SPECT images using 201T1C1 and 123Ⅰ-IMP. In this study, the volume of isotope accumulative and isotope defective regions were measured. Fusion of SPECT images was performed by the use of panning visualization software; Application Visualization Sys-tern Medical View (K. G. T.). The threshold of 3-D rendering was determined by conforming the volume of the hemisphere and of the tumor estimated on CT to the volume of 123Ⅰ-IMP and 201T1C1 accumulating area respectively.

Accumulative volume of 201T1C1 in the tumor de-creased remarkably at 7 days after radiosurgery (p < 0.01). Defective volume of peritumoral hypoperfusion was measured on 3-D SPECT. The average volume was 80.5±32.5cm3 before radiosurgery. It decreased by approximately 60% at 7 days after radiosurgery (p<0.05).

Analysis of 3-D SPECT images using two different isotope tracers is reliable and useful to evaluate early the changes of metabolism and peritumoral circulation in or around intracerebral tumors.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

関連文献

もっと見る

文献を共有