雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

A Case of Multiple Myeloma with Intracerebral Metastasis Kunyu HARADA 1,4 , Jun YOSHIDA 1 , Toshihiko WAKABAYASHI 1 , Kenichiro SUGITA 1 , Masatomo ICHIHARA 2 , Tomomitsu HOTTA 2 , Masaaki NAGAMATSU 3 1Department of Neurosurgery, Nagoya University School of Medicine 2Department of Internal Medicine, Nagoya University School of Medicine 3Department of Neurology, Nagoya University School of Medicine Keyword: Multiple myeloma , Metastasis , Cerebrum , Chemotherapy pp.1113-1117
Published Date 1992/10/10
DOI https://doi.org/10.11477/mf.1436900546
  • Abstract
  • Look Inside

Compared to leukemia, malignant lymphoma and other hematogenous tumors, multiple myeloma rarely metastasizes to the central nervous system. Intracerebral metastasis without involvement of the cranium itself is rarer. We report a case of Ig-G k-type multiple myeloma with metastasis to the left frontal lobe extending to the right basal ganglia without involvement of the cranium. A. 71-year-old male complained of exertional dyspnea and lumbago. His laboratory data revealed hyper-proteinemia and an abnormal increase in Ig-G (6117mg/ d/) in his serum. Serum protein immunoelectrophoresis revealed an IgG k-type band, and Bence-Jones protein was detected in his urine.

MMPP, VMCP, VIPP and MP chemotherapy was given, and serum IgG level decreased to a normal range. 21 months after his first admission, incontinence, dis-orientation, gait disturbance and apathy developed. CT-scan showed an isodense lesion with massive edema in the left frontal lobe and right basal ganglia. On MRI, a Gd-DTPA enhancing lesion was detected extending from the left frontal to the opposite frontal lobe through the splenium. No abnormal skull punched out lesions were noted.

Left frontal lobectomy was performed. Histopathology revealed plasmablastic myeloma cells with clear nucleole and eccentric nucleus in the cerebrum. He was diagnosed as having intracerebral metastasis of multiple myeloma without involvement of the cranium. UnfortunateHy, he died of pancytopenia and pneumonia. Our case suggests the possibility of metastasis via blood into the cerebrum.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

関連文献

もっと見る

文献を共有