A Case of Trochlear Nerve Neurinoma Presenting with Pathological Laughter Nozomi SASAKI 1 , Akihide MATSUDA 1 , Kiyomitsu KANOU 1 , Naoki OKA 1 , Jouji KOKUZAWA 1 , Yasuhiko KAKU 1 1Department of Neurosurgery, Asahi University Hospital Keyword: trochlear nerve , neurinoma , pathological laughter pp.909-913
Published Date 2020/10/10
DOI https://doi.org/10.11477/mf.1436204295
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 Trochlear nerve neurinomas are rare and solitary tumors without neurofibromatosis are extremely rare. We report a case of trochlear nerve neurinoma presenting with pathological laughter and diplopia.

 A 40-year-old male patient presented with diplopia and pathological laughter 2 months before admission. MRI showed a multicystic enhanced mass in the left tentorial incisura compressing the midbrain and the upper pons. The tumor was excised using the left trans-Sylvian approach with partial uncal resection. After excision of the tumor, the left trochlear nerve was identified on the surface of the lateral midbrain. The nerve was connected to the tumor. Pathological laughter completely resolved after the operation.

 This is the second reported case of trochlear nerve neurinoma presenting with pathological laughter. The lesion responsible for pathological laughter could be the midbrain, upper pons, diencephalon, or all of these.

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