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I.はじめに
脳の放射線壊死に関する症例報告は決して珍しいものではないが5,6,9,13),その治療について論じた報告は少ない.ことに神経膠腫に対する照射後の放射線障害の治療に関しては,腫瘍の再発との鑑別が難しいだけに,その治療効果の検討は十分に行い得ないことが多い.この点,下垂体腺腫症例においては,腫瘍の再発との鑑別が比較的容易であり,放射線障害の診断は下しやすく,治療効果の判定も行いやすい.ここでは,6例の下垂体腺腫症例で見られた脳の遅発性放射線障害についての概要を示すとともに,治療法についての検討を行い,他の頭蓋内悪性腫瘍,ことに神経膠腫例における放射線障害の診断,治療の糧とすることを目的とした.
Treatment for delayed brain injury after pituitary irradiation is discussed. Six cases with delayed brain in-jury were treated with a combination of dexamethasone or betamethasone, with heparin, glycerol, dextran 40 and some vasodilators. Two cases with temporal lobe syndrome were treated in the early stages of brain in-jury for a period of over 12 months were almost com-pletely cured, another two cases with chiasma syn-drome were treated in the relatively late stages, showed a partial improvement. One case which was irradiated 120 GY during 13 years did not improve.
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