青春早発症で発症した視床下部Hamartomaの1例

Hypothalamic Hamartoma with Precocious Puberty:case report

I．はじめに

　青春早発症を伴う視床下部hamartomaは稀な腫瘍である．われわれは最近この1例を経験し，手術的に亜全摘を行い，その組織中に電子顕微鏡でLH-RH分泌顆粒と思われる顆粒を証明し，また術後血中testosterone，およびLH-RH負荷試験でのLHの反応の正常化を認めたので文献的考察を加えて報告する．

A case of hypothalamic hamartoma with precocious puberty is presented and the literature of reported cases is reviewed.

An 8-year-old boy was admitted to our hospital because of precocious puberty and mental retardation. His genital development was Tanner's stage 4 and pubic hair was Tanner's stage 3. Bone age was 11 years. Plain CT showed an isodense mass in the suprasellar cistern which was not enhanced follow-ing contrast administration. Metrizamide CT cister-nography showed a filling defect in the suprasellar cistern.