ウサギ脳腫瘍モデルの作製

Rabbit Brain Tumor Model

I．はじめに

　悪性脳腫瘍の治療は，手術療法と補助療法とが組み合わされ，その経過中に種々の検査により経過が観察されるのだが，私たちが今日使っているマウスやラットの脳腫瘍モデルは，補助療法の実験モデルとしては十分であっても，手術操作や頻回の無菌的採血を行うには不自由であった．そこで私たちは，より大型な動物の脳腫瘍モデルを求めていたが，VX₂ウサギ皮膚癌の脳内移植により，手術操作と補助療法を行うに十分な脳腫瘍モデルを作製することができた．

We have established the rabbit brain tumor model. The domestic rabbits (Japanese White) inplanted theVX₂ rabbit epidermoid carcinoma cell were died within three weeks after the inplantation. These brains showed massive brain tumor remarkably infiltrating into the surrounding brain.

The flowcytometry of intracerebral VX₂ tumor revealed a monopeak at the 2C and relatively large amount of S-phase cells.

We think that this brain tumor model is more convenient for the combination treatment with operation and chemotherapy, because the rabbit brain is larger and intravenous injection is more easy than the rat or mouse.