実験的移植脳腫瘍の神経放射線学的検索

Neuroradiological Evaluation of An Experimentally Implanted Tumor into Cerebral Hemisphere of Neonatal Beagles

I．はじめに

　glioblastomaは，最も治療困難な脳腫瘍の1つであり，この腫瘍に対する外科手術，放射線療法，化学療法，免疫治療およびこれらの併用療法によるchallengeが続いている．

　しかしながら，これらの治療にもかかわらず，このglioblastomaのsurvival timeは極めて短く，さらに，生存してもADLは低く，満足できる状態だとはいえない．

Twenty-five neonatal beagles were used for this study.Gliosarcoma was injected into the cerebral hemisphere of 7neonatal beagles (Group I). These animals were thentreated by boron neutron capture therapy. The responseof the tumor to therapy was evaluated by serial CT scansand 3 times magnification of cerebral angiography. Theanimals were sacrificed at varying post-therapy periods forhistological study.

Fifteen neonatal beagles implanted gliosarcoma withouttherapy (Group II) and 3 normal controls without tumor(Group III) were subjected to the same follow-up studies.