Neurological Surgery No Shinkei Geka Volume 39, Issue 10 (October 2011)

A Case of Symptomatic Pituitary Metastases from Renal Cell Carcinoma Yuuta KAMOSHIMA 1 , Shunsuke TERASAKA 1 , Shuji HAMAUCHI 1 , Hiroyuki KOBAYASHI 1 , Shogo ENDO 1 , Yukiko KANNO 2 , Kimihiko KIMACHI 3 , Kiyohiro HOUKIN 1 1Department of Neurosurgery,Hokkaido University Graduate School of Medicine 2Department of Urology,Hokkaido University Graduate School of Medicine 3Department of Medicine Ⅱ,Hokkaido University Graduate School of Medicine Keyword: pituitary metastases , renal cell carcinoma , panhypopituitarism pp.999-1004
Published Date 2011/10/10
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 Symptomatic metastases to the pituitary from renal cell carcinoma are rare. We present a case of pituitary metastases from renal cell carcinoma showing panhypopituitarism. A 50-year-old man who had renal cell carcinoma with distant metastases in skin,bone and lymph nodes was referred to our department. Clinically he showed severe cognitive function disorder. Endocrinological evaluation revealed central adrenal and gonadal insufficiencies. Brain magnetic resonance imaging demonstrated a hemorrhagic mass in left frontal lobe and a sellar mass with supra sellar cistern extension. After hormonal replacement and surgical removal of the frontal tumor,he immediately recovered from his cognitive function disorder. Subsequently,whole brain radiotherapy for metastatic pituitary tumor was performed. At present,he is being treated with molecular targeting drugs for other distant metastases and he presents no neurological deficit. Palliative therapy for CNS metastases from renal cell carcinoma may result in better quality of life for patients with advanced stage of renal cell carcinoma.

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Neurological Surgery 脳神経外科
39巻10号 (2011年10月)
電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院