涙腺原発mucosa associated lymphoid tissue（MALT）-type lymphomaの1例

MALT-type Lymphoma of Lacrimal Gland: Case Report

Ⅰ．はじめに

　Mucosa associated lymphoid tissue（MALT）-type lymphomaとは粘膜関連リンパ組織から発生するB細胞低悪性度群non Hodikin lymphomaで，比較的稀な亜型である^1-10,12,13)．今回，涙腺原発MALT-type lymphomaの1例を経験したので文献的考察を加え報告する．

　A 72-year-old female presented with a lump in the left superior-lateral eyelid. The magnetic resonance imaging showed a well-delineated mass in the left lacrimal gland. The tumor was isointense on both the T1 and T2 weighted images, and it was homogenously enhanced with Gd-DTPA. Surgery via the trans-cranial approach revealed a pinkish and elastic-hard tumor. Total resection was successfully performed. The hematoxilyn-eosin staining of the surgical specimen showed a dense infiltrate of lymphocytes, which were composed predominantly of small lymphocytes, centrocyte-like cells, monocytoid cells, and occasionally transformed lymphocytes. The immunohistochemical findings for CD20, CD3, UCHL-1, CD23, CD5, cyclinD1, and bcl-2 were compatible with Mucosa Associated Lymphoid Tissue (MALT)-type lymphoma. The patient received local radiation therapy (30Gy / 15 fractions). She remained in complete clinical remission of the disease about one and a half years after treatment.