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Neurological Surgery No Shinkei Geka Volume 34, Issue 11 （November 2006）

Neurological Surgery 脳神経外科 34巻11号（2006年11月発行）

Japanese English

研究

ポリグルコール酸不織布フェルトとフィブリン糊による新しい硬膜閉鎖法―臨床応用140例の結果― A Novel Method of Dural Repair Using Polyglycolic Acid Non-woven Fabric and Fibrin Glue:Clinical Results of 140 Cases 寺坂俊介 ¹ , 岩﨑喜信 ² , 黒田敏 ² , 内田隆徳 ³ Shunsuke TERASAKA ¹ , Yoshinobu IWASAKI ² , Satoshi KURODA ² , Takanori UCHIDA ³ ¹手稲渓仁会病院脳神経外科 ²北海道大学大学院医学研究科神経外科 ³化学及血清療法研究所 ¹Department of Neurosurgery,Teine Keijinkai Hospital ²Department of Neurosurgery,Hokkaido University Graduate School of Medicine ³The Chemo-Sero-Therapeutic Research Institute キーワード： cerebrospinal fluid leakage , dural substitute , fibrin glue , non-stitch dural repair , polyglycolic acid Keyword: cerebrospinal fluid leakage , dural substitute , fibrin glue , non-stitch dural repair , polyglycolic acid pp.1109-1117

発行日 2006年11月1日 Published Date 2006/11/1

DOI https://doi.org/10.11477/mf.1436100302

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Ⅰ．はじめに

　脳神経外科の手術では硬膜欠損や硬膜縫合不全が生じる場合が少なからず存在する．硬膜欠損は外傷や髄膜腫の手術のみならず，外減圧術や頭蓋底手術でも起こりうる．また硬膜縫合不全は，高齢者の後頭蓋窩の手術や内視鏡手術などで硬膜の一次縫合ができない場合に起こりうる．このような場合に髄液漏やそれに引き続く感染，脳の陥頓による様々な合併症を防ぐ目的で代用硬膜が必要になる．

　われわれは2006年に生体組織に置換される代用硬膜としてポリグルコール酸不織布フェルト（PGAフェルト）とフィブリン糊との組み合わせを報告した¹⁶⁾．この生体適合性代用硬膜は硬膜としての高い閉鎖能や膠原線維への組織置換という特徴以外に，不織布ゆえ硬膜閉鎖に縫合操作を要しないという特徴をもっていた．髄液漏が縫合操作に制限が起こる部位で起こりやすいことを考えると，この代用硬膜の特徴は硬膜閉鎖には極めて有利に働くと考えられた．

　今回われわれは，臨床上の様々な硬膜欠損や硬膜縫合不全に対する本代用硬膜の臨床応用例を報告する．

　This paper presents a report based on the results obtained from clinical applications of a biocompatible dural substitute made of polyglycolic acid non-woven fabric and fibrin glue. The cases subjected to this study were the ones needing reconstruction of dura mater which had become defective due to injury or brain tumor and the ones in which primary suture of the dura mater was considered to be too difficult or inadequate with ordinary methods. The dural substitute was used in 140 cases during the period between June,2001 and July,2005. The operations were performed using the supratentorial approach in 66 cases and infratentorial approach in 74 cases. Among these procedures,39 cases were indicated for microvascular decompression,the commonest operation performed,then cranial base surgery in 27 cases and tumor resection in 24 cases,and so on. Lumber spinal fluid drainage or re-operation was required in 3 cases (2.1％) due to formation of post-operative cerebrospinal fluid leakage or subcutaneous accumulation of cerebrospinal fluid. With the dural substitute no infection was observed as a complication in any of the cases. Among the 140 cases presented this time,27 cases were cranial base surgery and 74 cases were performed,using the infratentorial approach. Nevertheless,the study showed that the closing ability of the dural substitute was adequate even in actual clinical settings it is reported above that the incidence rate of post-operative cerebrospinal fluid leakage or subcutaneous accumulation of cerebrospinal fluid which require additional intervention was only 2.1％.