痙攣の生化学的研究

Chemical Changes of the Brain During Convulsion

　1870年Jackson^1）は癲癇患者の臨床症状を観察し，中枢神経系に起因するものであることを報告し，1929年Berger^2）3）はEEGによる癲癇の診断を樹立した。Foerster^4）等はFocusの病理組織の研究により，その部の外科的切除を唱えたが，その後の研究でFocus性癲癇の大半と，Petitmalを起す側頭葉Focusに於ては，可視的な組織学的変化が存在しない事を明かにした。従つて神経生理学的現象が化学的変化の上に成立つ事が，明かになつて来た。之が生化学的障害を癲癇の基礎として考える様になつた。

　私共は癲癇即ち痙攣の経過に於けるエネルギー代謝と痙攣物質の脳代謝に及ぼす影響について研究したので次に報告する。

During the blood perfusion of cat's brain, con-vulsion was induced by Metrazol injection, andthe brain cortex tissue was the obtain after freez-ing. The value of chemical changes of the braincortex was greater than in the case of electricstimulation.

The nucleic acid fraction was separated by frac-tion collector after its hydrolysis, and the absorp-tion spectrum by Beckman's spectrophotmeter wasexamined.

The result was different from the case of ele-ctric stimulation, and it showed the tendency ofincrease in cytidine and adenosin and decreasein uridine and guanosine.

Similar results were obtained by acetylcholine-convulsion as in the case of electric stimulation.Chemical changes in diencephalon were less thanin the brain cortex.

Chemical changes found in trepanned rabit'sbrain between spreading depression and convultionwere quite opposite, namely increase to the caseof convulsion decreased in depression.