雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Biochemical Studies on γ-Aminobutyric Acid Seiichiro Yamasaki 1 , Tomoyoshi Shirane 1 , Yoshihiko Nishisa 1 , Moriyuki Takeshita 1 1Second Depertment of Internal Medicine, Faculty of Medicine, Kyushu University pp.497-502
Published Date 1960/4/1
DOI https://doi.org/10.11477/mf.1431906362
  • Abstract
  • Look Inside

 When γ-Aminobutyric acid was given to comatose patients (electro encephalographically), itProduced some excited fast wave in human subjects, and activated wave in cats during brainblood perfusion.

 The chemical changes of the cat's brain cortexwere about the same as those seen in cases byelectric stimulation.

 The increase of total nitrogen and the decreaseof amino acid nitrogen in acid soluble fractionof the brain cortex, and the decrease of totalnitrogen, the increase of amino acid nitrogen inlipid and nucleic acid fractions by Schneider'smethod, were studied.

 In respect to the clinical effects of γ-Aminobutylic acid, its administration brought about therecovery from hepatic coma.

 However in rabbits with hyper ammonemia, injection of γ-Aminobutyric acid resulted in fatherelevation of blood ammonia. This is suggestiveof the γ-Aminobutyric acid having no effect indecreasing blood ammonia level.

 Therefore, in the etiology of hepatic coma, other than increase of blood ammonia level mayalso play a role.


Copyright © 1960, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

関連文献

もっと見る

文献を共有