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Production of fbcal cerebral ischemia by occlusion of various intracranial cerebral arteries in gerbils Toru HAYAKAWA 1 , Toshiki YOSHIMINE 1 , Kazuo YAMADA 1 , Takehiko YANAGIHARA 2 , Yukitaka USHIO 1 , Heitaro MOGAMI 1 1Department of Neurosurgery, Osaka University Medical School 2Department of Neurology, Mayo Clinic pp.736-747
Published Date 1986/8/10
DOI https://doi.org/10.11477/mf.1431905821
  • Abstract
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Three kinds of experimental models for focal cerebral ischemia produced by occlusion of three different cerebral arteries in gerbils are described. The distribution of ischemia in each model corre-lates with the characteristic vascular territory of the occluded artery. The occlusion of the middle cerebral artery causes ischemia in the cerebral cortex and lateral caudo-putamen; the occlusion of the posterior communicating artery produces ischemia in the hippocampus, the lateral part of the thalamus and the superior and inferior colliculi; and the occlusion of the vertebro-basilar junction results in ischemia in the midbrain, pons, cere-bellum and the medial small portion of the thala-mus. The selection and combination of these ex-perimental models may be useful in investigating pathophysiologic, metabolic and histopathologic alterations associated with different types of focal cerebral ischemia.


Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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