Alzheimer病とPick病における脳波像の変遷とその病理学的背景—IV．局在性および発作性脳波異常と大脳萎縮

Sequential alteration of EEG patterns in presenile dementia and its underlying pathological changes: IV.Relationship between localized and paroxysmal EEG abnormalities and cerebral atrophy.

I．はじめに

　P病とA病はともに慢性進行性の大脳萎縮を示すが，病理学的には，一般にP病では側頭・前頭葉を主とする限局性萎縮，A病では全般性萎縮が特徴とされている。

　本論文では，このような病理学的変化の相違が脳波上にどのように反映されるかを明らかにするために，両疾患26例の脳波上の左右差・局在性異常および発作性異常について報告し，これらの所見と大脳萎縮過程の関係を検討する。

Abstract

　The purpose of this paper is to study a relationship between localized and paroxysmal EEG abnormalities and an atrophy of the cerebrum that was demonstrated on PEGs, CT scans and autopsy in Pick's and Alzheimer's diseases (12 and 14 cases, respectively).

　1) There was a difference between the two cerebral hemispheres in the amplitude of EEG components and in the degree of cerebral atrophy that was persisted over a long period of time, in all of the cases except for two Alzheimer cases.