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An Autopsy Case of Chronic Japanese Encephalitis Shiro Totsuka 1 , Tadashi Haneda 1 , Yutaka Matsumoto 1 , Hirotsugu Shiraki 2 1Department of Neuropsychiatry, School of Medicine, Chiba University 2Division of Neuropathology, Institute of Brain Research, Faculty of Medicine University of Tokyo pp.708-715
Published Date 1966/12/25
DOI https://doi.org/10.11477/mf.1431904365
  • Abstract
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The patient, 36-year-old male, had showed paresis on both legs, difficulty in urination and defecation and impaired speech after high fever lasting for 2 days at the age of 28. Thereafter he developed psychotic symptoms such as audi-tory hallucination and depressive state, while disturbance of coordination, paresis on upper limbs, muscular rigidity, forced laughing and weaping and nystagmus progressed.

In the terminal stage, he showed disorientated state and athetoid movement. 7 and 1/2 years after the onset of illness he expired (Fig. 1).

Pathoanatomically, the lesions were dissemi-nated throughout the central nervous system, especially in cerebellum, brain stem, thalamic nuclei, Ammon's horn and the cortices of tem-poral and frontal lobes (Fig. 2). The histologi-cal findings were as follows numerous glial nodules, diffuse proliferation of both micro-and macroglial cells, slight to moderate deterioration of nerve cells, occasionally two nucleic nerve cells, neuronophagy and perivascular lympho-cytic infiltrations (Fig. 3-13).

Above-mentioned findings were briefly discus-sed in special references to some viral encepha-litides of similar type from clinico-pathological view point. The authors concluded that the present case was presumably an unusual case of Japanese encephalitis with chronic course.


Copyright © 1966, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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