雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

AN AUTOPSY CASE OF HYPOGLYCEMIC COMA DUE TO PRIMARY LIVER CELL CARCINOMA Yutaka MATSUMOTO 1 , Shiro TOTSUKA 1 , Junzo KOIZUMI 1 , Teruo YONEZAWA 1 , Takahiko SUZUKI 1 , Mitsuyasu YAZAKI 1 1Neuropsychiatric Dept. School of Med. Chiba Univ. pp.721-726
Published Date 1965/7/1
DOI https://doi.org/10.11477/mf.1406201884
  • Abstract
  • Look Inside

The 66 year old man could not awake without a sugary diet every morning, since one month before admission to the hospital. The comatose state was improved by dietary measures or glucose administra-tion. The fasting blood sugar was found to be 20mg per 100cc (Fig.1). Laboratory findings suggested adisturbance of liver function (TABLE 1). On 62 th day after admissitn, death occurred in highly fever-ish and comatose condition.

Pathological findings:The liver weighed 2200 g and almost consisted of multiple hepatocarcinomas, while the pacreas revealed no obvious changes except an abscence the tail (Fig. 2, 3). Carcinoma cells showed a typical trabecular nature and contained abundant glycogen granules (Fig. 4).

The brain weighed 1330 grams and macroscopically presented no marked abnormality except the milky opacities of the leptomeninges. Microscopically, there were widespread degenerative changes in the neurons of the cerebral cortex, basal ganglia, cerebellum and olivary nuclei. The cerebral cortex revealed a shrin-granules kage of cell body associated nuclear pyknosis and a pseudolaminar loss of nerve cells, especially on the gyrus-valley. In the hippocampus a selectve degeneration of the end-plate occurred, so-called incrustation of Golgi-network and sclerotic shrinkage (Fig. 7). Purkinje cells, dentatous nerve cells and olivary nerve cells showed markedly a homogenising change which exhibited a disappearance of Nissl's bodies (Fig. 5, 6).

The above-mentioned pathoanatomical findings of the central nervous system, presumably due to the hepatogenic hypoglycemia, extremely resembled to the anoxic one. These changes in hypoglycemic con-dition were discussed with special reference to ano-xic changes of nervous tissue.


Copyright © 1965, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

関連文献

もっと見る

文献を共有