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Lentivirai vectors and gene therapy for neurological disorders Hiroyuki MIYOSHI 1 1Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba Keyword: レンチウイルス , HIV , 非分裂細胞 pp.21-29
Published Date 2001/2/10
DOI https://doi.org/10.11477/mf.1431901222
  • Abstract
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Retroviral vectors, derived from oncoretroviruses such as the Moloney murine leukemia virus, have been the most widely used for gene therapy applications because the vector genome integrates into the chromosomes of target cells resulting in stable expression of transgenes. However, a major problem with these retroviral vectors is the requirement for proliferation of target cells for integration, limiting their use for gene transfer into nondividing cells such as hepatocytes, myofibers, neurons, and hematopoietic stem cells.


Copyright © 2001, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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