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Cytokine and apoptosis in Parkinson's disease. Makio MOGI 1 , Hiroshi ICHINOSE 2 , Akifumi TOGARI 1 , Toshiharu NAGATSU 2 1Department of Pharmacology, School of Dentistry, Aichi-Gakuin University 2Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University Keyword: パーキンソン病 , サイトカイン , 神経栄養因子 , アポトーシス pp.516-525
Published Date 2000/8/10
DOI https://doi.org/10.11477/mf.1431901167
  • Abstract
  • Look Inside

Parkinson's disease (PD) is an aging-related neurodegenerative disorder with motor disturbances and is characterized by selective neuronal cell death of the nigrostriatal dopamine (DA) neurons by unknown causes. Sporadic PD is thought to be caused by the combined effects of the genes related to the risk factors and some environmental factors such as neurotoxins. We found for the first time that the levels of cytokines related to inflammatory or immune responses such as TNF-α, IL-1β, IL-2, IL-4, IL-6, EGF, TGF-a and TGF-β1 are increased in the brain (striatum) and in ventricular and spinal cerebrospinal fluid in PD. We also found increased IL-1β levels in the striatum of MPTP-treated PD mice, and increased TNF-α levels in the lesioned side of the substantia nigra and striatum of 6-0HDA-treated hemiparkinsonian rats. We also found that neurotrophins of NGF superfamily, BDNF and NGF, were drastically decreased in the substantia nigra, striatum, and putamen in PD. These increases in the levels of proinflammatory cytokines such as TNF-α or IL-1β, or the decreased levels of apoptosis-related neurotrophins such as BDNF may induce apoptosis.


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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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