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Amyotrophic lateral sclerosis and free radicals Koji ABE 1 1Department of Neurology, Okayama University Medical School Keyword: Cu/ZnSOD , アポトーシス , ミトコンドリア pp.275-281
Published Date 1999/4/10
DOI https://doi.org/10.11477/mf.1431901047
  • Abstract
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The role of free radicals is an important aspect in the molecular mechanism of selective motor neuron death in amyotrophic lateral sclerosis (ALS). After the discovery of Cu/Zn superoxide dismutase (SOD) gene mutations in familial ALS in 1993, clinical severity and the SOD activity was extensively investigated. However, no cor-relation between them was observed, and the results suggest an alternative mechanism other than simple free radical damage by the reduction of SOD activity in the mutant SOD. A specific active oxygen species in the crucial mechanism of motor neuron death has not yet been identified.


Copyright © 1999, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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