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Roles of nitric oxide and arachidonic acid metablities in synaptic plasticity. Katsuei SHIBUKI 1 1Laboratory for Neural Networks, Frontier Research Program pp.918-925
Published Date 1992/12/10
DOI https://doi.org/10.11477/mf.1431900288
  • Abstract
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Recently, membrane-permeable substances such as nitric oxide (NO) and arachidonic acid meta-bolites attract our attention because these can work as inter-cellular messengers in the brain. Synaptic plasticity is one of the phenomena where intercellular-messengers may play important roles. In this paper, possible roles of these substances was explained in two different types of synaptic plasticity, hippocampal long-term potentiation (LTP) and cerebellar long-term depression (LTD).

If maintenance of hippocampal LTP is attributed to sustained increase of glutamate release from presynaptic nerve terminals, effect of postsynaptic Ca2+ rise, which triggers LTP, must be transferred to presynaptic terminals by some membrane-permeable substances. Such hypothetical substances are calledas retrograde messengers and arachidonic acid metabolites and nitric oxide are the candidates.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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