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Membrane phospholipid metabolism in signal transduction. Yasunori KANAHO 1 , Yoshinori NOZAWA 1 1Department of Biochemistry, Gifu University School of Medicine pp.466-475
Published Date 1992/6/10
DOI https://doi.org/10.11477/mf.1431900244
  • Abstract
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External signals such as hormones, neurotransmitters and other molecules are transmitted into cells through several signal transduction pathways, resulting in the production of second messengers, to exert their biological actions. Many second messengers are poduced from membrane phospholipids by the action of phospholipases, effector enzymes. The well-known phospholipase as an effector enzyme is phosphoinositide-specific phospholipase C which produces two second messengers, inositol 1,4,5-tris-phosphate and diacylglycerol. Phospholipase A2 also seems to be an effector enzyme, since arachidonic acid produced by this enzyme from arachidonate-containing phospholipids acts as a putative second messenger. In addition, it has been found that phospholipae D couples with agonist receptors to produce phosphatidic acid which has second messegner-like activity. In this review, characteristics of these phospholipases and their activation mechanisms in response to agonists are described.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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