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The trisomy 16 mouse as an animal model for Down syndrome and Alzheimer's disease. Masatoyo NISHIZAWA 1,2 , Takeshi TABIRA 1 1National Institute of Neuroscience, NCNP 2Department of Neurology, Jichi Medical School pp.117-131
Published Date 1991/2/10
DOI https://doi.org/10.11477/mf.1431900116
  • Abstract
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Since it was found that syntenic gene loci are present between human chromosome 21 (HSA 21) and mouse chromosome 16 (MMU 16), including the gene encoding amyloid precursor protein (APP), trisomy 16 (Ts 16) mice have been extensively studied with expectation that this model may provide clues for understanding pathogenetic mechanisms involved in both Down syndrome (DS) and Alzheimer's disease (AD). Unfortunately, Ts 16 mice cannot survive to birth, and therefore the central nervous system cells with Ts 16 genotype have to be rescued in order to make it possible to study the effects of Ts 16 on brain maturation and aging.


Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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