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Molecular imaging using high-field magnetic resonance imaging:current concepts Makoto Sasaki 1 , Eri Shibata 1,2 1Department of Radiology, Iwate Medical University School of Medicine 2Department of Psychiatry, Iwate Medical University School of Medicine Keyword: high field MRI , susceptibility-weighted imaging , neuromelanin imaging , volume diffusion imaging pp.971-975
Published Date 2006/12/10
DOI https://doi.org/10.11477/mf.1431100420
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 The advent of high-field magnetic resonance imaging(MRI)provides novel molecular imaging techniques, which have not been available in conventional neuroimaging modalities. Myelin imaging using a short inversion-time inversion-recovery technique can depict myelin-density related contrast mimicking myelin-stained specimens by means of the synergic effects of proton density and T1, T2 relaxations. Iron imaging using a spin-echo technique can reveal the intracerebral iron content due to an apparent T2 relaxation enhancement effect. Susceptibility-weighted imaging generated by T2 relaxation and localized phase shift allows the visualization of minute venous structures within the cerebral parenchyma as a result of the blood oxygen level dependent effect, and it may aid in the visualization of vascular and/or metabolic reserve capacities in acute and chronic ischemias. By using neuromelanin imaging, we can noninvasively assess the depletion and/or dysfunction of dopaminergic and noradrenergic systems. Amyloid imaging using amyloidophilic compounds is a promising technique for the preclinical diagnosis of Alzheimer disease in the near future. Molecular imaging techniques using high-field MRI are powerful tools for investigating functional morphology in the normal or abnormal central nervous system.


Copyright © 2006, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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