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Diffusion tentor tractography Shigeki Aoki 1 , Yoshitaka Masutani 1 , Osamu Abe 1 1Department of Radiology, University of Tokyo Hospital Keyword: magnetic resonance imaging , diffusion tensor , cerebral white matter , pyramidal tract pp.964-970
Published Date 2006/12/10
DOI https://doi.org/10.11477/mf.1431100419
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 Diffusion tensor imaging is a technique to visualize cerebral white matter tracts and also to evaluate them quantitatively using diffusion indices such as fractional anisotropy(FA). The orientation of white matter tracts can be analyzed and tracked by the methods named as diffusion tensor tractography(DTT)or fiber tracking. Three dimensional relationship between the major white matter tracts(such as corticospinal tract, corticobulbar tract, optic radiation)and the lesions(such as infarcts, tumors, AVMs)was clearly visualized(by a freeware:dTV and VOLUME-ONE made by one of us). This information was helpful to know the prognosis of infarction in the early stage, and was useful in preoperative evaluation and planning of tumors and AVMs. Segmentation of the white matter using DTT and its quantitative analysis by FA and other diffusion indices〔so called tract specific analysis or Tract-of-Interest(TOI)analysis〕were useful to evaluate the degree of the white matter changes in degenerative changes such as Wallerian degeneration, ALS, schizophrenia, Alzheimer disease and etc. We found significant differences of FA between ALS and control group in the segmented corticospinal tract and corticobulbar tracts. We also found significant differences of FA between schizophrenia patients and controls in the anterior cingulum, fornix and uncinate fasciculus. Further technical development can be expected in both imaging acquisition and diffusion data analysis. With acquisition techniques such as parallel imaging or PROPELLER techniques on 3T MR imagers, we can now track cranial nerves from the brain stem to the orbit and internal auditory canal. With imaging analysis techniques such as RBF, we separately tracked components of the pyramidal tract and also made probability map using normalization technique.


Copyright © 2006, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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