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Vasopressin and aquaporin-2 San-e Ishikawa 1 1Department of Medicine, Jichi Medical School, Omiya Medical Center Keyword: 下垂体後葉 , 腎集合尿細管細胞 , cyclic AMP , 水透過性 pp.407-415
Published Date 2003/6/10
DOI https://doi.org/10.11477/mf.1431100323
  • Abstract
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 Arginine vasopressin(AVP)is a typical neuroendocrine hormone, which is synthesized at supraoptic and paraventricular nuclei of the hypothalamus, and released from posterior pituitary gland into blood stream. The antidiuretic action is the most important physiological action of AVP, and AVP is profoundly involved in urinary concentrating ability as a rate-limiting factor. In response to AVP, concentrated urine is produced by water reabsorption across renal collecting ducts. The aquaporin-2(AQP-2)water channel was discovered by Sasaki and his colleagues, and is an AVP-regulated water channel in collecting duct cells. There are two regulatory system:short-term and long-term regulation. Short-term regulation by AVP has been examined by immunocytochemistry and immunoelectron microscopy, and shown to involve cellular trafficking of AQP-2 to the apical membrane of collecting duct cells. AVP also regulates the total number of AQP-2 water channel in collecting duct cells, and this is noted as long-term regulation by AVP. AVP stimulates the expression of AQP-2mRNA, followed by the synthesis of AQP-2 protein. The upregulation of kidney AQP-2 expression is closely related to the non-suppressible release of AVP in the experimental models of SIADH, liver cirrhosis, congestive heart failure and adrenal insufficiency. Kidney AQP-2 expression has been quantitatively estimated by urinary excretion of AQP-2. In this review, I focus on the recent progress of AQP-2 research closely associated with release of AVP in both physiological and pathological states.


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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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