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Pathophysiology of lymphocytic infundibuloneurohypophysitis Takumi Abe 1 1Department of Neurosurgery, Showa University School of Medicine Keyword: リンパ球性漏斗下垂体後葉炎 , 下垂体前葉炎 , 中枢性尿崩症 , 下垂体機能低下症 pp.417-424
Published Date 2003/6/10
DOI https://doi.org/10.11477/mf.1431100324
  • Abstract
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 Lymphocytic infundibuloneurohypophysitis was firstly reported by Saito et al and Imura et al as a cause of idiopathic central diabetes insipidus. MR imaging with a contrast medium demonstrates thickening of the pituitary stalk, enlargement of the neurohypophysis, or both with homogeneous enhancement. Histological examination reveals the posterior pituitary that is heavily infiltrated by lymphocytes with occasional plasma cells and other inflammatory cells. In early reports of the disorder, the lesion seemed to be limited to the neurohypophysis, but the present review showed cases with a combination of hypopituitarism and diabetes insipidus. Some of them showed partial hypopituitarism. In typical cases of lymphocytic infundibuloneurohypophysitis, conservative care with steroids and hormone replacement are recommended. Surgical intervention should be avoided because the natural course of the disorder may be self-limited. Pathophysiology of the disorder is still unknown. The unique clinical manifestations of the disorder are discussed.


Copyright © 2003, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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