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The discovery of PrRP(prolactin-releasing peptide)and its physiological significance Ryo Fujii 1 , Shuji Hinuma 1 1Discovery Research Laboratories 1, Pharmaceutical Research Division, Takeda Chamical Industries Ltd. Keyword: prolactin-releasing peptide , GPCR , オーファン pp.371-380
Published Date 2003/6/10
DOI https://doi.org/10.11477/mf.1431100319
  • Abstract
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 Guanine-nucleotide-binding protein(G protein)-coupled receptors(GPCRs)and their ligands play important roles in the regulation of various physiological phenomena. We have developed an approach to identify orphan GPCR ligands, and succeeded in the identification of an endogenous ligand”prolactin(PRL)-releasing peptide(PrRP)”for an orphan GPCR, hGR3, obtained from human pituitary gland. Although PrRP was initially found to show a specific PRL release promoting activity in the rat anterior pituitary cells, recent researches have revealed that PrRP has various functions in addition to the promotion of PRL secretion. In this article we describe how PrRP was discovered and the current status of the research on the physiological functions of PrRP and its receptor.


Copyright © 2003, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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