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Actions of CRH and its family peptides Keiko Arai 1,2 , Tamotsu Shibasaki 2 1Arai Clinic 2Department of Physio-logy, Nippon Medical School Keyword: corticotropin-releasing hormone , CRH , urocortin , urocortin Ⅱ , CRH receptor type 1 , CRH receptor type 2 pp.381-388
Published Date 2003/6/10
DOI https://doi.org/10.11477/mf.1431100320
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 Corticotropin-releasing hormone(CRH)plays an important role in stress responses such as ACTH secretion from the pituitary and changes in autonomic nervous system, immune system, behavior and mood. These actions of CRH are mediated by its two G-protein coupled receptor, CRH receptor type 1 and 2. As members of CRH peptide family, urocortin, urocortin Ⅱ and urocortin Ⅲ have been characterized. Urocortin shows inhibition of food intake, modification of anxiety, influence on cardiovascular system. Urocortin Ⅱ and Ⅲ, specific CRH type 2 receptor ligands, decreases food intake and modify anxiety.


Copyright © 2003, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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