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Microarray analysis classifies multiple sclerosis subgroups Jun-ichi SATOH 1,2 1Department of Immunology, National Institute of Neuroscience, NCNP 2Department of Bioinformatics and Neuroinformatics, Meiji Pharmaceutical University Keyword: DNAマイクロアレイ , 階層的クラスター解析 , 多発性硬化症 , テーラーメイド医療 pp.582-599
Published Date 2006/8/10
DOI https://doi.org/10.11477/mf.1431100167
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Multiple sclerosis(MS)is an inflammatory demyelinating disease of the central nervous system(CNS)white matter mediated by an autoimmune process, whose development is triggered by a complex interplay of multiple genetic and environmental factors. MS shows a great range of heterogeneity in terms of the disease course, lesion distribution, therapeutic response to IFNβ, and pathological aspects such as inflammation, antibody deposition, oligodendrocyte apoptosis, and axonal degeneration. These observations suggest that MS is a kind of neurological syndrome caused by different immunological mechanisms leading to the final common pathway that provokes inflammatory demyelination. DNA microarray technology is a novel approach to systematically monitoring the global expression of a large number of genes. It gives us new insights into the complexity of molecular interactions promoting the autoimmune process in MS. By microarray analysis followed by hierarchical clustering, we recently found that gene expression profiling of peripheral blood T lymphocytes discriminates four molecularly distinct subgroups of MS, associated with differential disease activity and therapeutic response to IFNβ. These observations suggest that microarray analysis is valuable for designing and optimizing personalized treatment for heterogeneous populations of MS.


Copyright © 2006, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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