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Anti-Alzheimer disease effects by NSAID and antioxidant Takashi Morihara 1 , Masatoshi Takeda 1 , Sally A Frautschy 2 , Greg M Cole 2 1Department of Post-Genomics and Disease, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine 2Department of Neurology, University of California Los Angeles Keyword: アルツハイマー病 , 非ステロイド系抗炎症剤 , nonsteroidal anti-inflammatory drugs , NSAIDs , 酸化ストレス , 予防 pp.445-452
Published Date 2005/6/10
DOI https://doi.org/10.11477/mf.1431100061
  • Abstract
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Both inflammation and oxidative stress are involved in Alzheimer disease(AD)brain pathology. Both anti-inflammatory drugs and antioxidants those could prevent neuronal damage have been candidates for anti-AD drugs. Amyloid pathology is the specific and upstream pathology of AD. Series of recent studies revealed that both drugs could suppress amyloid pathology. Amyloid pathology in APP transgenic mice is suppressed by nonsteroidal anti-inflammatory drug(NSAID)and curucumin which is anti-inflammatory and antioxidative. In vitro, Aβ42 production is reduced by a subset of NSAIDs. Aβ aggregation is inhibited by curcumin. Here, we will discuss epidemiological/clinical studies, basic research and recently revealed effects of these drugs.


Copyright © 2005, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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