Histologic Features of Non-steroidal Anti-inflammatory Drug (NSAID) -Induced Colitis Takashi Yao 1 , Takayuki Matsumoto 2 , Mitsuo lida 3 , Koichi Kurahara 4 , Chiharu Hirota 5 1Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University 2Department of Endoscopic Diagnostics and Therapeutics, Kyushu University Hospital 3Division of Gastroenterology, Department of Medicine, Kawasaki Medical School 4Department of Medical and Clinical Science Graduate School of Medical Sciences Kyushu University 5Department of Gastroenterology, Nippon Steel Yawata Memorial Hospital Keyword: 非ステロイド系抗炎症剤 , 腸炎 , アポトーシス pp.1159-1167
Published Date 2000/8/25
DOI https://doi.org/10.11477/mf.1403104845
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 We reviewed the histologic features of non-steroidal anti-inflammatory drug (NSAID) -induced colitis, using biopsy specimens from 16 cases. Clinically, they were divided into three types ; ulcerative-type (10 cases), colitis-type (3 cases) and ileitis-type (3 cases) . In addition to them, a surgical case of ileal diaphragm disease was also evaluated. Histologically, they were classified as non-specific enteritis-type (12 cases), ischemic enteritis-type (1 case), hemorrhagic enteritis-type (2 cases) and eosinophilic enteritis-type (1 case) . Diaphragm disease was considered to be a special form of non-specific enteritis-type, histologically (or ulcerative-type clinically).

 In spite of mild inflammation and mild epithelial damage, mitotic figures and apoptotic bodies are occasionally seen in non-specific enteritis-type. It is suggested that apoptosis plays an important role in ulcer formation of NSAID-induced enteritis. Every type essentially had a different histologic features, which suggests different mechanism in each of them. However, they shared some features which indicates that the mechanisms of each type might be complicated by overlapping.

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