抗体検査をどのように行うか

How to Perform Autoantibody Testing for Autoimmune and Inflammatory Diseases of Peripheral Nerves and Muscles

自己抗体の測定は，多くの末梢神経・筋疾患の診療に欠かせない検査となった。その臨床的意義は抗体ごとに異なり，検査精度や検出されるアイソタイプ・サブクラス，疾患活動性との関連など，臨床医が理解しておくべきことは多い。また，保険診療として実施できない自己抗体検査も多く，限られた医療資源の中で，検査結果を誤解なく日常診療に生かすために，臨床医は常に最新情報をアップデートしておくことが求められる。

Abstract

Measurement of autoantibodies is essential for the management of several peripheral nerve and muscle diseases. The clinical significance of autoantibody testing differs for each antibody. In addition, clinicians must understand several issues including the accuracy of the test, isotype and subclass distribution, and its relationship to disease activity. Moreover, many autoantibody tests are not covered by health insurance. With limited medical resources, clinicians are required to be up-to-date with the latest information to utilize test results in daily practice without misunderstanding.