神経・精神領域の薬剤相互作用

Drug Interactions in Neurology and Psychiatry

薬剤相互作用のうち，薬物動態学的相互作用は複数の薬剤の生体内動態が相互に影響し合うことで血中濃度変動を生じるもので，薬物代謝酵素（シトクロムP450，UDPグルクロン酸転移酵素）と薬物トランスポーター（P糖蛋白質など）が主に関与している。同時に使用する薬剤が増えるほど相互作用を生じるリスクが上がるため，可能な限り薬剤数を減らす努力とともに，相互作用のメカニズムと注意すべき薬剤を知っておくことが重要である。

Abstract

Among drug-drug interactions, pharmacokinetic drug interactions are those in which multiple drugs interact to produce fluctuations in their blood concentrations, and mainly involve drug-metabolizing enzymes (cytochrome P450, UDP-glucuronyltransferase) and drug transporters (P-glycoprotein, etc.). The risk of drug interactions along with an increase in the number of drugs being used simultaneously; therefore, it is important to know the mechanisms of drug interactions, and the drugs to be wary of, as well as to make efforts to reduce the number of drugs used as much as possible.