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Japanese

Dynamic Functional Connectivity in Resting-State fMRI and Its Clinical Applications Kazushi Shinagawa 1,2 , Yuri Terasawa 3 , Satoshi Umeda 3 1Department of Psychology, Keio University Graduate School of Human Relations 2Japan Society for the Promotion of Science 3Keio University Faculty of Letters Keyword: fMRI , 動的機能結合 , 安静時脳活動 , うつ病 , 認知症 , dynamic functional connectivity , resting-state brain activity , major depressive disorder , dementia pp.1267-1273
Published Date 2021/11/1
DOI https://doi.org/10.11477/mf.1416201929
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Abstract

The conventional analysis assumes a constant mental state during scanning and assesses the strength of functional connectivity as the average of the entire fMRI data. However, it is suggested that even at rest, functional connectivity may change with time, and the conventional analysis has not been able to fully evaluate its properties. To overcome this limitation, many studies propose an index called dynamic functional connectivity (dFC) or time-varying functional connectivity (TVFC) or the chronnectome. This article reviews the significance and methods of dFC, examples of its application in clinical studies, and its limitations. Finally, we discuss its potential for clinical application.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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