Cell Therapy Using Peripheral Mononuclear Cells Preconditioned by Oxygen-Glucose Deprivation for Ischemic Stroke Masahiro Hatakeyama 1 , Itaru Ninomiya 1 , Osamu Onodera 1 , Takayoshi Shimohata 2 , Masato Kanazawa 1 1Department of Neurology, Brain Research Institute, Niigata University 2Department of Neurology, Gifu University Graduate School of Medicine Keyword: 脳梗塞 , 再生医学 , 細胞療法 , 低酸素低糖刺激 , 末梢血単核球 , cerebral ischemia , regenerative medicine , cell therapy , oxygen-glucose deprivation , peripheral blood mononuclear cell pp.1097-1103
Published Date 2020/10/1
DOI https://doi.org/10.11477/mf.1416201655
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Many studies in recent years have reported cell therapies using embryonic stem cells, induced pluripotent stem cells, and bone marrow-derived mononuclear cells for cerebral ischemia. However, obtaining these cells is challenging, and these cell therapies require complicated procedures to prepare cells for administration. Notably, peripheral blood mononuclear cells (PBMCs) are a useful cell source for clinical applications because cell collection is easier. In this review, we report the therapeutic effects of PBMCs preconditioned by oxygen-glucose deprivation (OGD-PBMCs) on cerebral ischemia. Cell therapies using tissue-protective OGD-PBMCs might be a simple and ideal therapeutic strategy against ischemic stroke.

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